Based on the Chrysler 300 platform, the 2006 Dodge Charger inherits dual five-star safety ratings. Dual front airbags determine the size of the front passengers and modify airbag deployment accordingly. For added protection, Dodge offers optional front and rear side-curtain airbags. Engineered to quell the need for these supplemental restraints, optional all-speed traction control and electronic stability control modulate the brakes and throttle to keep the vehicle on course. Standard ABS with brake assist help slow the car when necessary.

Modern-day technological features include Sirius satellite radio, a center console-mounted rear-seat video entertainment system, and DVD-based navigation. Satellite radio is available on SXT and R/T models, with Sirius offering a free one-year subscription. Video entertainment may also be optioned on SXT and R/T Chargers, while navigation is offered solely on R/T versions. The video entertainment system features a seven-inch LCD screen built into the back of the center console.